منابع مشابه
It takes two to tango
The vertebrate inner ear has time and again surprised neurobiologists by adding new wrinkles to known mechanisms of cellular signaling. among those surprises, was the discovery that nicotinic acetylcholine receptors (related to those that excite muscle) inhibit cochlear hair cells when acetylcholine (aCh) is released from efferent neurons. Inhibition occurs because calcium entering through the ...
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Meiosis is a special type of cell division that produces haploid gametes from diploid parental cells. Chromosome number is reduced during meiosis because a single round of DNA replication is followed by two rounds of chromosome segregation (Fig. 1). Fusion of two gametes during sexual reproduction restores the diploid chromosome complement. The second division of meiosis (the equational divisio...
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An unsolved mystery in cell biology is how unusually large secretory cargoes are exported from the endoplasmic reticulum. In this issue, Santos et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603072) report the function of a Mia2/cTAGE5 transcript fusion, named TALI, in the endoplasmic reticulum export of chylomicrons and very low-density lipoproteins, but not collagen XII.
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Until now, clinicians have been relying solely on LH activity-dependent triggering of final oocyte maturation and thus taken it for granted that the natural midcycle FSH surge is biologically redundant. However, it is time to question this paradigm. Evidence from clinical studies hint that in a yet-to-be-defined subset of patients, dual LH and FSH surge is advantageous compared with LH-only sur...
متن کاملIt Takes T to Tango
Of three recently cloned T-type voltage-gated calcium channels, alpha(1g) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures. In this issue of Neuron, Kim et al. inactivated alpha(1g), and resultant mice were deficient in relay cell bursting and resistant to GABA(B) receptor-dependent ab...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.332205